Overview

The Friedreich’s Ataxia (FRDA) Transcriptomic Atlas is an interactive Shiny application that provides open access to harmonised transcriptomic analyses across publicly available FRDA bulk RNA-seq datasets. This resource was developed to enable researchers, clinicians, and students to explore and compare differential expression between FRDA and controls across many diverse cell or tissue types and FRDA models.

The Atlas serves as a central reference for transcriptome-wide alterations in FRDA, supporting hypothesis generation, biomarker discovery, candidate gene prioritisation, and data reuse for downstream integrative analyses. All analyses were performed using a consistent bioinformatic framework to ensure comparability across studies. Details of the datasets, quality control, and analytical pipelines are available in the associated publication currently on BioRxiv.

Users are encouraged to consult the paper for methodological details:

Users must cite the FRDA Transcriptomic Atlas publication in any derivative analyses, figures, or reports generated from this resource. Users must also cite the original studies from which the data were derived. Please refer to the ‘Datasets’ section within the app for details on each dataset and its original publication.

Open FRDA Transcriptomic Atlas

Thank You

Thank you for stopping by! I hope you find the FRDA Transcriptomic Atlas a useful resource for your research.